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Club Noyau

discussion group on nuclear dynamics, nuclear architecture and genome integrity & expression

session 2021


Meetings are maintained on-line for the duration of the restrictions of assembly in the context of the pandemic of Covid19.




The Speakers

Upcoming Speakers


Gene expression

Andreas Mayer

Max Planck Institute for Molecular Genetics


Berlin (Germany).

We study the key mechanisms that underlie the regulation of chromatin-mediated transcription by RNA polymerase II in differentiated mammalian cells and during cell differentiation. Specifically, we aim to understand how post-initiation regulatory events are established in a dynamic chromatin environment in vivo and how these regulatory mechanisms control and coordinate cellular differentiation


Cell biology

Alfonso Fernández Álvarez

Center for Developmental Biology of Andalusia


Seville (Spain).

Centrosomes are the major microtubule center in the cell and are responsible for spindle nucleation, the vehicle for chromosome segregation during cell division. In certain cases, the spindles self-assemble in the absence of centrosomes; for example, this situation occurs frequently in female meiosis. In our lab, we have generated a system using fission yeast to understand the molecular basis behind spindle self-assembly that will help shed light on acentrosomal meiosis, a crucial event for understanding gametogenesis.

Past Speekers - Session 3


Gene expression

Mathieu Rougemaille

Institut de Biologie Integrative de la Cellule (I2BC)

CNRS - Gif-sur-Yvette

Our team works on the post-transcriptional mechanisms involved in the control of sexual differentiation in the fission yeast Schizosaccharomyces pombe. Specifically, we focus our research on the role of RNA-binding proteins and long non-coding RNAs in shaping gene expression profiles during the mitosis to meiosis transition. We use a combination of genetic and biochemical tools as well as genomic and protein/RNA imaging techniques.


Chromatin dynamics

Karine Dubrana

Institut de Biologie François Jacob

CEA - Fontenay aux Roses

Our research focuses on the role of nuclear organization and chromatin dynamics in the maintenance of genome stability. In particular, we aim at defining how nuclear organization and chromatin status (euchromatin versus heterochromatin) influences the detection, processing and subsequent repair of DNA lesions.

Past Speekers - Session 2


Pierre Therizols

Gebi Team - UMR Inserm 944. CNRS 7212

Hôpital Saint-Louis

Our research focuses on studying the functional role of the reorganisation of heterochromatin during early development. We use a combination of microscopy  and epigenome editing technologies to investigate the contribution  of the histone variant H3.3 and its chaperone Daxx in pericentromeric spatial organization of ground-state embryonic stem cells. 


Maxim Greenberg

Chromatin dynamics in mammalian development

Institut Jacques Monod

" We strive to gain a clear understanding of the profound epigenetic consequences of DNA methylation in a window of development, which occurs in the first week of mouse embryogenesis, and the second of human, but the repercussions of which can ripple throughout life."


Chromatin Dynamics

Past Speakers - Session 1



Camille Lobry

Laboratoire de Hématopoïèse normale et pathologique

Gustave Roussy - Inserm / Université Paris Saclay

My research focuses on the role of non-coding genome in the development of blood cancers and most particularly Acute Myeloid Leukemia. I use combination of epigenetics, genomic and screening technologies based on high throughput sequencing to interrogate enhancer dysregulation and long non-coding RNA function in leukemia.

Charlène Boumendil

Laboratoire "Fonctions non-conventionnelles des pores nucléaires"

Institut Jacques Monod - Équipe V. Doye

My research focuses on the role of nuclear pores in chromatin organization and gene expression during senescence.


Chromatin organization


Genome Integrity

Thèrese Wilhelm

Laboratoire Genome Instability and Stability (SInG)

Institut Cochin / Inserm

Our laboratory is interested in the subtle balances of between the different mechanisms that orchestrate DNA repair, protecting against genetic instability while allowing genetic diversity (antibodies, gametes, molecular evolution).

Stéphane Marcand

Laboratoire Telomeres and Repair of Chromosomes

CEA / Inserm

Dicentric chromosomes are abnormal structures that can be important contributors to pathological states. The general aim of our lab is to dissect the pathways preventing dicentrics formation and decipher how dicentric are broken upon mitotic exit and cytokinesis.​


Chromosome segregation



OCT 22



Andreas Mayer - "Mechanisms of genome transcription regulation".


Alfonso Fernández Álvarez - "Spindle self-assembly in fission yeast meiosis"

No social time this time either. Social distancing and... be patient, wine and cheese await at the end of the Covid-19 restrictions.

Past events

Session 3


Mathieu Rougemaille - "A scaffold lncRNA shapes mitosis to meiosis switch"


Karine Dubrana - "The heterochromatin protein Sir3 interacts with Sae2 to regulate its function at DNA double strand breaks"

Session 2


Pierre Therizols - "Daxx safeguards pericentromere integrity in embryonic stem cells"


Maxim Greenberg - "Early Embryonic Events, Life-Long Epigenetic Memory"

Session 1


Camille Lobry - "CRISPRi screening of clustered regulatory elements reveal functional cooperating dependencies in cancer"


Charlène Boumendil - "Chromatin organization and gene expression in senescence: from the global to the fine scale"


Therese Wilhelm - “Centriole splitting and increased Microtubule Stability under Replication Stress cause Numerical Chromosomal Instability”


Stéphane Marcand - "A Telomere Protection Pathway Targeting the Rad50 Complex"

Institut Jacques Monod

Bâtiment Buffon, 15 rue Hélène Brion, 75205 Paris CEDEX 13 - France

L'Institut Jacques Monod (IJM), unité mixte de recherche du CNRS et de l'université Paris Diderot, est l'un des principaux pôles de recherche fondamentale en biologie de la région parisienne.


Our Sponsors



Club Noyau 2020


Nuclear dynamics discussion group


January 30th, 2020


IJM -  15 rue Hélène Brion, 75005 Paris 

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